Analysis of prophages harbored by the human-adapted subpopulation of Staphylococcus aureus CC398
10 juillet 2013
Staphylococcus aureus clonal complex 398 is a livestock-associated pathogen that poses a worldwide threat because of its ability to colonize and infect both humans and animals. We used high-resolution whole-genome microarrays, prophage profiling, immune evasion cluster characterization and (...)
Pre-travel Consultation: Evaluation of Primary Care Physician Practice in the Franche-Comté Region.
5 juillet 2013
BACKGROUND: Primary care physicians (PCP) are first in line to provide adequate pre-travel medical advice. Little data are available on the content of pre-travel PCP consultations in France. We undertook an observational survey to assess the level of specific knowledge among PCPs on health (...)
North-south palaeohydrological contrasts in the central Mediterranean during the Holocene: tentative synthesis and working hypotheses
28 juin 2013
On the basis of a multi-proxy approach and a strategy combining lacustrine and marine records along a north-south transect, data collected in the Central Mediterranean within the framework of a collaborative project have led to reconstruction of high-resolution and well-dated palaeohydrological (...)
Combination of branched GDGTs and testate amoebae for the reconstruction of past climate change in a French peatland
28 juin 2013
Peatlands are important archives for the reconstruction of past environmental changes because of their high rates of peat accumulation due to the low rate of plant litter decomposition. Branched glycerol dialkyl glycerol tetraethers (GDGTs) are complex lipids of high molecular weight, recently (...)
Dysenteric syndrome due to Balantidium coli: a case report.
27 juin 2013
A 28-year-old man was hospitalized for a dysenteric syndrome that had developed during the previous days. Physical examination revealed abdominal pains, fever, vomiting and more than ten liquid stools per day. Fresh stool examination showed numerous mobile ciliated trophozoites of Balantidium (...)
Human monocyte-derived dendritic cells exposed to microorganisms involved in hypersensitivity pneumonitis (actinomycetes, mycobacteria and filamentous fungi) induce a Th1-polarized immune response.
27 juin 2013
Context: Hypersensitivity pneumonitis (HP) is an immunoallergic disease characterized by a prominent interstitial infiltrate composed predominantly of lymphocytes secreting inflammatory cytokines. Dendritic cells (DCs) are known to play a pivotal role in the lymphocytic response. However, their (...)
Inhibitory effect of chromogenic culture media on the growth of Rhodotorula: relevance to the diagnosis of Rhodotorula spp. infections.
27 juin 2013
With the increasing incidence and diverse etiologies of fungal infections, chromogenic yeast culture media are increasingly used for routine diagnosis. Rhodotorula species, which are characterized by the production of carotenoid pigments, are considered as emerging opportunistic pathogens. We (...)
Hydrochemical dynamics of TOC and NO3- contents as natural tracers of infiltration in karst aquifers
21 juin 2013
Analysis of Total Organic Carbon (TOC) and NO3- contents in the water at six springs in the province of Malaga (Southern Spain), sampled under different hydrologic conditions, revealed two different hydrochemical behaviour patterns for these natural tracers of infiltration. TOC content (...)
Climate and vegetation changes during the Lateglacial and early-middle Holocene at Lake Ledro (southern Alps, Italy)
19 juin 2013
Adding to the on-going debate regarding vegetation recolonisation (more particularly the timing) in Europe and climate change since the Lateglacial, this study investigates a long sediment core (LL081) from Lake Ledro (652ma.s.l., southern Alps, Italy). Environmental changes were reconstructed (...)
Assessing the <i>in situ</i> bioavailability of trace elements to snails using accumulation kinetics
13 juin 2013
The bioavailability of trace elements in soils is conditioned by both physico-chemical and biological parameters. In this study, the accumulation kinetics of cadmium (Cd), lead (Pb), arsenic (As) and antimony (Sb) were determined for 3 industrially impacted sites to assess the bioavailability (...)
Transmission ecosystems of Echinococcus multilocularis in China and Central Asia.
9 juin 2013
SUMMARY From continental to regional scales, the zoonosis alveolar echinococcosis (AE) (caused by Echinococcus multilocularis) forms discrete patches of endemicity within which transmission hotspots of much larger prevalence may occur. Since the late 80s, a number of hotspots have been (...)
Assessing the in situ bioavailability of trace elements to snails using accumulation kinetics.
3 juin 2013
In this study, the accumulation kinetics of cadmium (Cd), lead (Pb), arsenic (As) and antimony(Sb) were determined for 3 industrially impacted sites to assess the bioavailability of these contaminantsto the garden snail (Cantareus aspersus). Mono and multivariate regressions allowed the (...)
Case-Based Reasoning adaptation of numerical representations of human organs by interpolation
29 mai 2013
Case-Based Reasoning (CBR) and interpolation tools can provide solutions to unknown problems by adapting solutions from other problems already solved. We propose a generic approach using an interpolation tool during the CBR-adaptation phase. The application EquiVox, which attempts to design (...)
Case-Based Reasoning adaptation of numerical representations of human organs by interpolation
29 mai 2013
Case-Based Reasoning (CBR) and interpolation tools can provide solutions to unknown problems by adapting solutions from other problems already solved. We propose a generic approach using an interpolation tool during the CBR-adaptation phase. The application EquiVox, which attempts to design (...)
Climate, vegetation and land use as drivers of Holocene sedimentation: A case study from Lake Saint-Point (Jura Mountains, eastern France)
22 mai 2013
A multiproxy approach to a sediment sequence at Lake Saint-Point in the French Jura Mountains gives evidence of a strong coupling between changes in terrestrial and lacustrine ecosystems throughout the Holocene. The early Holocene (11,700-10,200 cal. BP) is characterised by the recovery of (...)
Les activités économiques des petites villes du jura comtois au temps des Habsbourg (1492-1678)
19 mai 2013
Fox baiting against Echinococcus multilocularis: Contrasted achievements among two medium size cities.
11 mai 2013
In Europe, most cities are currently colonized by red foxes (Vulpes vulpes), which are considered to be the main definitive host of the zoonotic cestode Echinococcus multilocularis. The risk of transmission to humans is of particular concern where high fox populations overlap with high human (...)
Ammonia exposure promotes algal biomass in an ombrotrophic peatland
3 mai 2013
Nitrogen pollution affects many peatlands with consequences for their biodiversity and ecosystem function. Microorganisms control nutrient cycling and constitute most of the biodiversity of peatlands but their response to nitrogen is poorly characterised and likely to depend on the form of (...)
Global biomass burning: A synthesis and review of Holocene paleofire records and their controls
30 avril 2013
Climate and vegetation changes along Lateglacial and early-mid Holocene in Lake Ledro (Southern Alps, Italy).
30 avril 2013
Minimum inhibitory concentrations of amphotericin B against Candida krusei isolates from a French teaching hospital laboratory: a retrospective study over 8 years.
25 avril 2013
Recent studies have shown decreased susceptibility of Candida krusei to amphotericin B (AmB), in addition to its inherent resistance to fluconazole. The susceptibility of C. krusei to AmB was studied in the Parasitology-Mycology laboratory of Grenoble Teaching Hospital, France. Between 2003 and (...)
Borrelia crocidurae meningoencephalitis, West Africa.
25 avril 2013
Borrelia crocidurae-associated relapsing fever is endemic to West Africa and is considered benign. We report 4 patients with B. crocidurae-associated neurologic symptoms; 2 of their cases had been misdiagnosed. Frequency and severity of this disease could be underestimated; molecular methods (...)
Tephrochronological study in the Maccarese lagoon (near Rome, Italy) : Identification of Holocene tephra layers
23 avril 2013
Paleohydrology reconstruction and Holocene climate variability in the South Adriatic Sea
23 avril 2013
Holocene paleohydrology reconstruction is derived combining planktonic and benthic stable oxygen and carbon isotopes, sea surface temperatures (SSTs) and oxygen isotope composition of seawater (δ18Ow) from a high sedimentation core collected in the South Adriatic Sea (SAS). Core chronology is (...)
Mass-movement and flood-induced deposits in Lake Ledro, southern Alps, Italy: implications for Holocene palaeohydrology and natural hazards
18 avril 2013
High-resolution seismic profiles and sediment cores from Lake Ledro combined with soil and riverbed samples from the lake's catchment area are used to assess the recurrence of natural hazards (earthquakes and flood events) in the southern Italian Alps during the Holocene. Two welldeveloped (...)
Evaluating the effect of habitat connectivity on the distribution of the lesser horseshoe bat using landscape graphs
18 avril 2013
Weakening processes in thrust faults: insights from the Monte Perdido thrust fault (southern Pyrenees, Spain)
12 avril 2013
Deglacial and Holocene vegetation and climatic changes at the southernmost tip of the Central Mediterranean from a direct land-sea correlation
11 avril 2013
Despite a large number of studies, the long-term and millennial to centennial-scale climatic variability in the Mediterranean region during the last deglaciation and the Holocene is still debated, including in the southern Central Mediterranean. In this paper, we present a new marine pollen (...)
Oxidation reactivity of zinc-cysteine clusters in metallothionein
11 avril 2013
Evaluating the reactivity of the metal-thiolate clusters in metallothionein (MT) is a key step in understanding the biological functions of this protein. The effects of the metal clustering and protein environment on the thiolate reactivity with the hydrogen peroxide (H2O2) were investigated by (...)
Shear-enhanced compaction bands formed at shallow burial conditions; implications for fluid flow (Provence, France)
3 avril 2013
Field observations of highly porous and permeable sandstone in the Orange area (S-E Basin, France) show that networks of shear-enhanced compaction bands can form in a contractional regime at burial depths of about 400 m ± 100 m. These bands show equal compaction and shear displacements, are (...)
Prospection spéléologique au sud du massif de Bjelasica (Monténégro) : Repères géologiques.
30 mars 2013
Primaquine for Radical Cure of Plasmodium vivax and Plasmodium ovale Malaria: An Observational Survey (2008-2010).
29 mars 2013
Since 2008, the French guidelines have promoted the systematic use of 30 mg/day of primaquine for the radical cure of Plasmodium vivax and Plamodium ovale infections. We observed three relapses in 10 patients with P vivax acquired in French Guiana. No relapses were seen in West African P ovale (...)
Landscape effects in small mammal populations exhibiting density outbreaks and on their interactions with predators and parasites
23 mars 2013
Some species of small mammals (rabbits, prairie dogs, pikas, voles, etc.) have been traditionally perceived as pests and targeted for control on a very large scale despite their importance as key-stone species in their native ecosystems. During the 90s, a number of studies have shown that small (...)
Landscape, host diversity and functional invariants of Echinococcus multilocularis transmission: lessons from a study case
23 mars 2013
The loss or gain of certain host species may either dilute or amplify the risk of pathogen and parasite infection through direct or indirect effects. The relative contribution of host communities combined with climate and landscape characteristics on non-vector-borne parasite transmission to (...)
Ranking field site management priorities according to their metal transfer to snails.
22 mars 2013
Current soil quality evaluation does not include an assessment of metal bioavailability to organisms. However, sentinel soil-dwelling invertebrates can be used for such an assessment. This study aims to establish the modulating soil parameter of metal bioavailability to snails and a procedure (...)
Drivers of Echinococcus multilocularis Transmission in China: Small Mammal Diversity, Landscape or Climate?
21 mars 2013
BACKGROUND: Human alveolar echinococcocosis (AE) is a highly pathogenic zoonotic disease caused by the larval stage of the cestode E. multilocularis. Its life-cycle includes more than 40 species of small mammal intermediate hosts. Therefore, host biodiversity losses could be expected to alter (...)
Lidar in Mediterranean agricultural landscapes: reassessing land use in the Mauguio
21 mars 2013
The value of lidar data for the study of forested areas has been repeatedly demonstrated, recording large numbers of previously unknown sites and features where most survey methods are ineffective. However, the question of the value of lidar in cultivated areas already investigated through (...)
Du lard ou du cochon. Economie d'un type céramique de La Tène C-D : les pots " de type Besançon "
21 mars 2013
Clonal dissemination of Pseudomonas aeruginosa isolates producing extended-spectrum β-lactamase SHV-2a.
20 mars 2013
From January to December 2011, 24 Pseudomonas aeruginosa strains producing the extended-spectrum β-lactamase SHV-2a were identified in 13 hospitals in France. With one exception, all the strains belonged to the same clone. Double-disk synergy tests with cefepime and clavulanate were able to (...)
Immunosuppression-mediated hepatitis B reactivation diagnosed following an investigation into suspected transfusion-transmitted hepatitis B.
20 mars 2013
In August 2006, the regional unit for nosocomial infection control (ARLIN) was notified of a case of symptomatic acute hepatitis B (HBV) infection in an immunosuppressed 87-year-old patient who had received a blood transfusion five months previously. Immunosuppression for the treatment of a (...)
Antibiotics involved in the occurrence of antibiotic-resistant bacteria: a nationwide multilevel study suggests differences within antibiotic classes.
20 mars 2013
OBJECTIVES: To identify the antibiotics potentially the most involved in the occurrence of antibiotic-resistant bacteria from an ecological perspective in French healthcare facilities (HCFs). METHODS: This study was based on data from the French antimicrobial surveillance network (ATB-RAISIN, (...)
Evaluation of the number of opportunities for hand hygiene in hospital: A new methodological approach.
20 mars 2013
OBJECTIVE: To assess the number of alcohol-based hand rubbing (ABHR) opportunities in different wards of a university hospital. MATERIALS AND METHODS: The amount of care procedures was measured in nine wards (4 medical wards, 4 surgical wards, 1 intensive care unit) over a two-year period. We (...)
10-Fold increase (2006-11) in the rate of healthy subjects with extended-spectrum β-lactamase-producing Escherichia coli faecal carriage in a Parisian check-up centre.
20 mars 2013
OBJECTIVES: In 2006, 0.6% of healthy subjects living in the Paris area had extended-spectrum β-lactamase (ESBL)-producing Escherichia coli in their gut. To assess the evolution of this rate, a study identical to that of 2006 was conducted in 2011. PARTICIPANTS AND METHODS: Healthy adults who (...)
National multidrug-resistant bacteria (MDRB) surveillance in France through the RAISIN network: a 9 year experience.
20 mars 2013
BACKGROUND: In the mid-1990s, the prevalence rate of multidrug-resistant bacteria (MDRB) in French hospitals was high and control of MDRB spread then became a major priority in the national infection control programme (ICP). METHODS: To evaluate the impact of the ICP, a national coordination of (...)
CC9 Livestock-Associated Staphylococcus aureus Emerges in Bloodstream Infections in French Patients Unconnected With Animal Farming.
20 mars 2013
We report 4 bloodstream infections associated with CC9 agr type II Staphylococcus aureus in individuals without animal exposure. We demonstrate, by microarray analysis, the presence of egc cluster, fnbA, cap operon, lukS, set2, set12, splE, splD, sak, epiD, and can, genomic features associated (...)
Hospital environmental contamination with Enterobacteriaceae producing extended-spectrum β-lactamase.
20 mars 2013
Alternatives to carbapenems in ESBL-producing Escherichia coli infections.
20 mars 2013
OBJECTIVES: The authors had for objective to assess the activity of a wide panel of antibiotics on extended-spectrum-β-lactamase producing Escherichia coli isolates (ESBL-Ec), because of the sharp increase of their frequency, leading to an increased use of carbapenems. MATERIAL AND METHODS: We (...)
Detecting and quantifying mites in domestic dust: A novel application for real-time PCR.
19 mars 2013
Holocene land-use evolution and associated soil erosion in the French Prealps inferred from Lake Paladru sediments and archaeological evidences
19 février 2013
A source-to-sink multi-proxy approach has been performed within Lake Paladru (492 m a.s.l., French Prealps) catchment and a 6-m long sediment sequence retrieved from the central lacustrine basin. The combination of minerogenic signal, specific organic markers of autochthonous and allochthonous (...)
Urbanization, trace metal pollution, and malaria prevalence in the house sparrow.
28 janvier 2013
Anthropogenic pollution poses a threat for the environment and wildlife. Trace metals (TMs) are known to have negative effects on haematological status, oxidative balance, and reproductive success in birds. These pollutants particularly increase in concentration in industrialized, urbanized and (...)
Holocene land-use evolution and associated soil erosion in the French Prealps inferred from Lake Paladru sediments and archaeological evidences
21 janvier 2013
A source-to-sink multi-proxy approach has been performed within Lake Paladru (492 m a.s.l., French Prealps) catchment and a six-meter long sediment sequence retrieved from the central lacustrine basin. The combination of minerogenic signal, specific organic markers of autochthonous and (...)
The long and winding road: combining least cost paths and network analysis techniques for settlement location analysis and predictive modelling
9 janvier 2013
In this paper, we describe an exploratory analysis of the possibilities of combining least cost path analysis and network analysis techniques. Accessibility is a potentially important site location factor. So far, the definition of accessibility has been approached through the creation of (...)
Above- and belowground linkages in Sphagnum peatland: climate warming affects plant-microbial interactions
8 janvier 2013
Peatlands contain approximately one third of all soil organic carbon (SOC). Warming can alter above- and belowground linkages that regulate soil organic carbon dynamics and C-balance in peatlands. Here we examine the multiyear impact of in situ experimental warming on the microbial food web, (...)
Coupling inter-patch movement models and landscape graph to assess functional connectivity
8 janvier 2013
Landscape connectivity is a key process for the functioning and persistence of spatially-structured populations in fragmented landscapes. Butterflies are particularly sensitive to landscape change and are excellent model organisms to study landscape connectivity. Here, we infer functional (...)
Past and future landscape dynamics in wooded pastures of the Jura Mountains under climate change
23 décembre 2012
Modeling socio-ecological feedback effects in the implementation of payments for environmental services in pasture woodlands
23 décembre 2012
Dynamics of forage production in pasture-woodlands of the Swiss Jura Mountains under projected climate change scenarios
23 décembre 2012
A contextual analysis of observed land-use and vegetation changes in two wooded pastures in the Swiss Jura Mountains
23 décembre 2012
Les prairies : biodiversité et services écosystémiques
23 décembre 2012
À partir d'une analyse bibliographique, les auteurs étudient la composition, l'organisation et le rôle de la biodiversité des prairies permanentes en fonction de leur régime d'exploitation. Une première partie décrit la diversité des prairies, du paysage aux espèces. Une seconde est centrée sur les (...)
Metamorphic and geochronogical study of the Triassic El Oro metamorphic complex, Ecuador: Implications for high-temperature metamorphism in a forearc zone
7 décembre 2012
In the forearc of the Andean active margin in southwest Ecuador, the El Oro metamorphic complex exhibits a well exposed tilted forearc section partially migmatized. We used Raman spectroscopy on carbonaceous matter (RSCM) thermometry and pseudosections coupled with mineralogical and textural (...)
Introducing the human factor in predictive modelling: a work in progress
19 octobre 2012
In this paper we present the results of a study into integrating socio-cultural factors into predictive modelling. So far, predictive modelling has largely neglected the social and cultural dimensions of past landscapes. To maintain its value for archaeological research, therefore, it needs new (...)
Introduction of a combination vector to optimise the interpolation of numerical phantoms
21 juillet 2012
Phantoms are 3-dimensional (3D) numerical representations of the contours of organs in the human body. The quality of the dosimetric reports established when accidental overexposures to radiation occur is highly dependent on the phantom's reliability with respect to the subject. EquiVox is a (...)
The Modagspace project: Lidar data and landscape archaeology in southern France (Languedoc)
26 août 2011
Thermodynamic modeling and thermobarometry of metasomatized rocks
3 juin 2011
Determining the P-T conditions at which metasomatism occurs provides insight into the physical conditions at which fluid-rock interaction occurs in the crust. However, application of thermodynamic modeling to metasomatized rocks is not without pitfalls. As with "normal" metamorphic rocks, the (...)